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Titulo: Heterosynaptic Metaplastic Regulation of Synaptic Efficacy in CA1 Pyramidal Neurons of Rat Hippocampus
Tipo: revista internacional
Fecha: 4,2004
Revista: Hippocampus
JCR Journal; Impact Factor: 4.500
Volumen: 14(8)
Paginas: 1011-1025
ISSN: 1050-9631
Editorial: Wiley-Liss
Hoboken, NJ 07030 (EEUU)


The induction threshold, and the magnitude and direction of changes in synaptic plasticity may depend on the previous history of neuronal activity. This phenomenon, termed "metaplasticity", could play an important role in integration processes by coordinating the modulation of synapses. Although methaplasticity has been analyzed extensively, its underlying cellular mechanisms remain largely unknown. Using in vitro electrophysiological and computer simulation approaches, we investigated the contribution of the slow Ca++ -dependent afterhyperpolarization (saHP) in the metaplastic control of the induction of long-term potentiation (LTP) at convergent CA3-CA1 pyramidal neuron synapses. We report that classical conditioning protocols may lead to the simultaneous induction of a sustained homosynaptic LTP and a potentiation of the saHP that endured. _ 1h. The saHP potentiation dramatically altered the skipe responses of the CA1 pyramidal neuron. Of particular interest was the reduction of the CA1 neuron excitability and, consequently , of the capacity of a nonpotentiated synaptic input to elicit spikes while the saHP was potentiated. This reduction in excitability temporarily prevented nonpotentiated synaptic inputs to exhibit an LTP induced by presynaptic tetanization. This metaplacticity was strongly resistant to increases in the magnitude of synaptic tetanization protocols. We propose that this heterosynaptic metaplasticity, mediated by intrinsic cellular mechanisms, triggered by brief periods of activity, and relying on changes of a slow Ca++ -activated K+ current, may contribute to adjusting the efficacy of synaptic connections and shaping network behavior to regulate integration processes.

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